Dr. Temesgen Samuel

Dr. Temesgen Samuel, DVM, Ph.D.
Assoc. Professor of Pathobiology
Phone:  334-724-4547
Email:  tsamuel@mytu.tuskegee.edu


Addis Ababa University DVM
Hannover School of Vet. Med  Ph.D.
University of Erlangen-Nuremberg  Postdoctoral
Burnham Institute for Medical Research  Postdoctoral

Selected Publications:

Samuel, T. and Wirtu G. An attempt to treat Paratuberculosis diarrhea by acupuncture. Bulletin of Animal Health and Production in Africa, 1995, 43: 157-158.

Samuel, T., Tareke, F., Wirtu, G., and Kiros, T. Bacteriological study of Ethiopian isolates of Dermatophilus congolensis. Trop Anim Health Prod, 30: 145-147, 1998.

Samuel, T., Bose, R., and Schelp, C. Purification of a 28 kDa Babesia (Theileria) equi antigen and a 29 kDaspurious erythrocyte antigen from in vitro culture through ion exchange chromatography. Vet Parasitol, 86: 63-70, 1999.

McShea, A., Samuel, T., Eppel, J. T., Galloway, D. A., and Funk, J. O. Identification of CIP-1-associated regulator of cyclin B (CARB), a novel p21-binding protein acting in the G2 phase of the cell cycle. J Biol Chem, 275: 23181-23186, 2000.

Samuel, T. and Bose, R. The 18 kDa antigen of Theileria equi is a specific but less abundant protein also expressed by parasites cultured in vitro. Vet Res Commun, 25: 169-178, 2001.

Samuel, T., Weber, H. O., Rauch, P., Verdoodt, B., Eppel, J. T., McShea, A., Hermeking, H., and Funk, J. O.  The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax. J Biol Chem, 276: 45201-
45206, 2001.

Weber, H. O., Samuel, T., Rauch, P., and Funk, J. O. Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. Oncogene, 21: 3207-3212, 2002.

Dohi, T., Okada, K., Xia, F., Wilford, C. E., Samuel, T., Welsh, K., Marusawa, H., Zou, H., Armstrong, R., Matsuzawa, S., Salvesen, G. S., Reed, J. C., and Altieri, D. C. An IAP-IAP complex inhibits apoptosis. J Biol
Chem, 279: 34087-34090, 2004.

Wang, Z., Cuddy, M., Samuel, T., Welsh, K., Schimmer, A., Hanaii, F., Houghten, R., Pinilla, C., and Reed, J. C. Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. J Biol Chem, 279: 48168-48176, 2004.

Samuel, T., Okada, K., Hyer, M., Welsh, K., Zapata, J. M., and Reed, J. C. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res, 65: 210-218, 2005.

Samuel, T., Welsh, K, Lober, T., Togo, SH., Zapata, JM, and Reed, JC Distinct BIR Domains of cIAP1 Mediate Binding to and Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 2 and Second
Mitochondrial Activator of Caspases. J Biol Chem, 281: 1080-1090, 2006.

Santoro, M. M., Samuel, T., Mitchell, T., Reed, J. C., and Stainier, D. Y. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet, 39: 1397-1402, 2007.

Garrison, J B, Samuel, T, Reed, J C.TRAF2-binding BIR1 domain of c-IAP2//MALT1 fusion protein is essential for activation of NF-[kappa]B. Oncogene 28, 1584–1593, 2009.

Samuel, T., Fadlalla, K., Turner, T., Yehualaeshet, T. E. The flavonoid quercetin transiently inhibits the activity of taxol and nocodazole through interference with the cell cycle. Nutrition & Cancer 62, 1025-1035, 2010.
PMCID: PMC3021775.

Fadlalla, K., Watson, A., Yehualaeshet, T. E., Turner, T., Samuel, T. Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival. Anticancer Res, 31: (1) 233-241, 2011. PMCID: PMC3124362.

Abdela W., Graham M., Habtemariam T., Samuel, T. and Yehualaeshet, T. Effects of orange juice pH on the survival, urease activity and DNA profiles of Yersinia enterocolitica and Yersinia pseudotuberculosis stored at
4 degree celcius. Journal of Food Safety, 31(4):487-496, 2011. 

Samuel T, Fadlalla K, Mosley L, Katkoori V, Turner T, Manne U. Dual-mode interaction between quercetin and DNA-damaging drugs in colon cancer cells. Anticancer Research 32(1):61-71, 2012. PMID: 22213289.

Katkoori VR, Shanmugam C, Jia X, Vitta SP, Sthanam M, Callens T, Messiaen L, Chen D, Zhang B, Bumpers HL, Samuel T, Manne U. Prognostic Significance and Gene Expression Profiles of p53 Mutations in Microsatellite-Stable Stage III Colorectal Adenocarcinomas. PLoS One, 7(1): Epub Jan 19, 2012. PMID:

Rodriguez, S., Fadlalla, K, Graham, T., Tameru, B., Fermin, CD. and Samuel, T. Immunohistological evaluation of AKT protein activation in canine mast cell tumors. Journal of Comparative Pathology 2012 Jan 28. [Epub ahead of print]. PMID: 22289273.

Abdela W., Graham M., Habtemariam T., Yehualaeshet, T and Samuel, T. Novel genomic tools for simultaneous, specific and real-time detection of bio-threat and frequently encountered food-borne
pathogens. Journal of Food Protection, 75(4), 660-74, 2012. PMID: 22488053

Samuel, T., Rodriguez, S. Ex vivo maintenance of primary cancerous mast cells is augmented by fibroblasts (in preparation).