John P. Davidson, Department Head and Associate Professor
Location: Armstrong Hall 201A
Office Phone: 334-727-8822
E-mail: jdavidson@mytu.tuskegee.edu

Biographical Sketch: 
A comprehensive bioinformatics approach to examine  how global gene expression is related to chromosome structure in Bacteria. We have obtained a temperature-sensitive gyrase mutant (gyrBts) which shows a dramatic decrease in the level of supercoiling in a reporter plasmid at the near-restrictive temperature.   Alteration of expression of individual genes in the mutant vs normal strain is also observed at the near-restrictive temperature.  We seek to compare global expression of genes of a mutant and normal strain by microarray analysis of the transcriptome.  We further propose to compare transcriptomes of normal and mutant strains by deep sequencing analysis.

Research Interest:

  • Microbiology

Representative Publications:

1.   John P. Davidson and L. S. Williams. 1979. Regulation of Isoleucine-Valine Biosynthesis in Salmonella typhimurium:  The Effect of hisU on Repression Control. J. Mol.Biol.27:229-235.

2.   John P. Davidson and L. S. Williams. 1979. Relaxed Control of RNA Synthesis during  Nutritional Shiftdowns of a hisU  Mutant of Salmonella typhimurium.  Biochem.    Biophys. Res. Commun. 88:682-687.

3.   Wilson, Donella J., J. P. Davidson and L. S. Williams. 1981. Anomalies in The Guanosine Polyphosphate Metabolism:  Effect of the hisU Mutation.  Biochem. Biophys. Res. Commun.  103:319-326

4.   John P. Davidson, Donella J. Wilson and L. S. Williams. 1982. The Role of A hisU  Gene in The Control of Stable RNA Synthesis in Salmonella typhimurium.  J. Mol. Biol. 157:237-264.

5.   John P. Davidson and Donella J. Wilson. 1991. Evidence for Isoleucine as A Positive Effector of The ilvBN  Operon of in Salmonella typhimurium. Biochem. Biophys. Res. Commun. 178:934-939

6.   Davidson, John P.,J. Chiu, W. Session, V. Suppiramaniam E. Munir. 1995. The Effect of   Temperature on DNA Supercoiling in A gyrB  Mutant of Salmonellla typhimurium. Journal of Cellular Biochemistry, Supplement 19A.